Swallow the pill whole with a glass of water. Droxia 2. Women should use an effective form of birth control during treatment with this medicine and for at least 6 months after the last dose. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. * Approximation only. It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly. Is the initiation of non-invasive dental hygiene procedures* contra-indicated? Among them, 20 people (0.21%) have Tooth extraction. All rights reserved. This site complies with the HONcode standard for trustworthy health information: verify here. Other drugs that have the same active ingredients (e.g. Drowsiness 4. Be careful when using a regular toothbrush, dental floss, or toothpick. It is often used in polycythemia vera. © 2021 eHealthMe.com. Neutrophil count < 2000/mm^3 (unless on hydroxyurea therapy) Neutrophil count < 1000/mm^3 for patients on hydroxyurea therapy; Prothrombin Time > 17 seconds; Partial thromboplastin Time > 43 seconds; History of excessive bleeding in the context of previous procedures including surgery and dental extractions Hydrea (hydroxyurea) is an antineoplastic (anti-cancer) agent used to treat melanoma, resistant chronic myelocytic leukemia, and recurrent, metastatic, or inoperable carcinoma of the ovary and primary squamous cell (epidermoid) carcinomas of the head and neck.Hydrea is available in generic form. generic drugs) are not considered. Hydroxyurea can temporarily lower the number of white blood cells in your blood which increases the chance of getting an infection. https://www.webmd.com/drugs/2/drug-7818/hydroxyurea-oral/details All information is observation-only, does not establish causal relationship, and has not been supported by scientific studies or clinical trials unless otherwise stated. Check with your medical doctor before having any dental work done. Hydroxyurea has active ingredients of hydroxyurea. If a family member, friend, or caregiver needs to give hydroxyurea to you, they also need to follow these steps: 1. Most likely your drugs were not studied in clinical trials based on patients like you. the different options for dental treatment before, during and after oncological treatment, published in the scientific literature. Live virus vaccinations (eg, nasal flu virus vaccine) should not be given while you are using hydroxyurea. Tooth extraction is found among people who take Hydroxyurea, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. Chemical stability of hydroxyurea (HU) oral solutions. He is aware I am taking Hydroxyurea. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Talk to your doctor if you have concerns about this risk. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Clinical examination revealed brown patches on the hands, arm, and the dorsal surface of feet and hyperpigmented longi-tudinal bands on the fingernails, while toenails were almost Find everything you need to know about Hydroxyurea (Hydrea), including what it is used for, warnings, reviews, side effects, and interactions. While you are being treated with hydroxyurea, do not have any immunizations (vaccinations) without your doctor's approval. Nausea 6. Siklos Available Dosage Forms: 1. Diarrhea 3. It is a medication used to treat myeloid leukemia and cancers of the head and neck. Hydroxyurea (Hydrea) is an oral medication used to treat several types of cancers including chronic myelogenous leukemia (CML), acute myelogenous leukemia (AML), head and neck cancer, malignant melanoma, ovarian cancer, and polycythemia vera (a disorder of the bone marrow). Start now. On eHealthMe, our answer is simple: run your own phase IV clinical trial. Patients can bring a copy of the report to their healthcare provider to ensure that all drug risks and benefits are fully discussed and understood. This medicine may increase your risk of having lung or breathing problems (eg, interstitial lung disease). If you had radiation treatment in the past, this medicine might cause your skin to become very red when you have radiation again. Hydrea 3. Tooth extraction is found among people who take Hydroxyurea, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. There really is no need to take up hospital appointment/surgery time. eHealthMe is studying from 9,863 Hydroxyurea users now. To this effect a PubMed-Medline® search was made using the following keywords: chemotherapy, can-cer therapy, dental management, oral mucositis, neurotoxicity, intravenous bisphosphonates and jaw osteonecrosis. Common drugs people take besides Hydroxyurea *: Common side effects people have besides Tooth extraction *: Check whether Tooth extraction is caused by a drug or a condition. The use of the eHealthMe site and its content is at your own risk. This study sought to determine whether there was an association between sickle cell disease (SCD) and dental caries in African-American adults. Will you have Sick Sinus Syndrome with Stelara? ... Be careful when using a regular toothbrush, dental floss, or toothpick. You may need to stop using this medicine several days before you have medical tests. o Leave hydroxyurea in the provided packaging until it is ready to be taken. Dosage of drugs is not considered in the study. Do not take other medicines unless they have been discussed with your doctor. Hydroxyurea is a prescription medicine. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. FIGURE 1. Advertising revenue supports our not-for-profit mission. (A) Representative standard curve for analysis of hydroxyurea concentration using the colorimetric method of Fabricius and Rajewsky,12 with a resultant linear curve, r2 = 0.979, P < 0.001. Hydroxyurea can be taken with or without food but at the same time each day. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. Hydroxyurea has other beneficial effects, including a decrease in neutrophils and monocytes (intervening in the inflammatory cascade), an increase in red blood cell deformability, and a decrease in the adhesive receptors in the erythrocyte membrane. View detailed reports from patients taking Hydroxyurea who experienced dry mouth. Portions of this document last updated: Feb. 01, 2020. Avoid contact sports or other situations where bruising or injury could occur. It is recommended that patients use the information presented as a part of a broader decision-making process. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. An Infection 2. Learn about side effects, warnings, dosage, and more. Dentists and their support staff in the UK are highly trained and very capable of controlling blood loss after extraction. Hydroxyurea (Hydrea®) is thought to inhibit DNA synthesis and prevent cell division, but does not interfere with the production of RNA or protein. Make sure any doctor or dentist who treats you knows that you are using this medicine. Hydroxyurea can temporarily lower the number of white blood cells in your blood which increases the chance of getting an infection. Blood tests may be needed to check for unwanted effects. (B) Stability of 100 mg/mL hydroxyurea solutions prepared at room temperature (circles), with <5% loss of chemical activity over Learn about hydroxycarbomide and side effects at Patient Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Hydroxycarbamide, also known as hydroxyurea, is a medication used in sickle-cell disease, chronic myelogenous leukemia, cervical cancer, and essential thrombocythemia. (2012) “Family Guide to Hydroxyurea Therapy”. If a pregnancy occurs while using the medicine, tell your doctor right away. It can also lower the number of platelets, which are necessary for proper blood clotting. Copyright © 2021 IBM Watson Health. Capsule Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Antimetabolite If you can, avoid people with infections. Talk with your doctor before using this medicine if you plan to have children. It is based on hydroxyurea (the active ingredients of Hydroxyurea) and Hydroxyurea (the brand name). It comes in two presentations; capsules and tablets. Tooth extraction has been reported by people with metastases to bone, multiple myeloma, osteoporosis, breast cancer, rheumatoid arthritis. Hydroxyurea is more active against resting cells, however, making the combination of hydroxyurea and ddI attractive for targeting a reservoir not addressed by other anti-HIV drugs. In sickle-cell disease it increases fetal hemoglobin and decreases the number of attacks. This content does not have an Arabic version. The control group, those who were not taking aspirin, and the patients who had been taking 100 mg aspirin and antihypertensive medication daily were included at each center. Decreased Appetite 2. The phase IV clinical study is created by eHealthMe based on reports of 9,659 people who have side effects when taking Hydroxyurea from the FDA, and is updated regularly. The exact mechanism by which hydroxyurea works to treat cancer is not understood. Running one of the largest drug safety studies in the world, eHealthMe is able to enable everyone to run personal clinical trial. If experienced, these tend to have a Severe expression 1. In addition to regular annual dental care, thalassemia patients should be evaluated by a dentist to determine if bony changes requiring orthodontic treatments have developed. So how do you know what your drugs can do to you? would he have to refer me to hospital, I worry how long it will take as it is painful, also would I...days when it has a half-life of just 12 hours! 9,659 people reported to have side effects when taking Hydroxyurea. The phase IV clinical study is created by eHealthMe based on reports of 9,659 people who have side effects when taking Hydroxyurea from the FDA, and is updated regularly. It is taken by mouth. Vomiting Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. Low Levels Of A Type Of White Blood Cell Called Neutrophils 3. If you miss a dose of hydroxyurea, do not take an extra dose or two doses at one time. o Whenever possible, give hydroxyurea to yourself and follow the steps below. The study uses data from the FDA. eHealthMe is studying from 16,270 Tooth extraction patients now. All rights reserved. In people with cancer, hydroxyurea acts as a substitute for some parts that cancer cells need to grow. Mine - upper left … I've had the exact same experience Judy. o Keep hydroxyurea out of reach of children and pets. Some reports may have incomplete information. dental clinic for multiple restorative, endodontic treatments, and some uncomplicated extractions; oral pigmented lesions were not reported in her medical records. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Drug information provided by: IBM Micromedex. Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Hydroxyurea oral capsule (Hydrea, Droxia) is used to treat certain cancers and sickle cell disease. If orthodontics are recommended, they will be covered by insurance, since their necessity is disease-related. All rights reserved. Tooth extraction and drugs with ingredients of hydroxyurea, Fentanyl Citrate Preservative Free vs. Trileptal, Krill Oil and Cimetidine drug interaction. Use a sunscreen and protective clothing to protect your skin. Many years ago I was also a Dental Nurse. Some men who use this medicine have become infertile (unable to have children). However, close dental and orthodontic monitoring is crucial. Tell your doctor right away if you have darkening or reddening of the skin. Men should use an effective form of birth control during treatment and for at least 1 year for Droxia® and Hydrea® and at least 6 months for Siklos® after the last dose to prevent pregnancy in a sexual partner. Excerpts used with permission. Low Levels Of White Blood Cells If experienced, these tend to have a Less Severe expression 1. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Hydroxyurea. I would suggest that you have warm drinks only and through a straw. Mechanism of action Hydroxyurea belongs to a class of medications called antimetabolites . Furthermore, recent studies have shown that virus is present, for many years, in those with viral loads below the limit of detection of currently available tests. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. From: Pulmonary Manifestations of Pediatric Diseases, 2009. In the U.S. 1. I have been on Hydroxyurea for 6 years. I am going to ask my Oncologist about this. Levalbuterol Hydrochloride: 12 people, 60.00%, Ketorolac Tromethamine: 9 people, 45.00%, Esomeprazole Magnesium: 5 people, 25.00%, Sertraline Hydrochloride: 5 people, 25.00%, Periodontal Disease (disease that attacks the gum and bone and around the teeth): 14 people, 70.00%, Anaemia (lack of blood): 14 people, 70.00%, Osteonecrosis Of Jaw (death of bone of jaw): 13 people, 65.00%, Fatigue (feeling of tiredness): 13 people, 65.00%, Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 12 people, 60.00%, Osteoporosis (bones weak and more likely to break): 12 people, 60.00%, Osteomyelitis (infection of bone): 12 people, 60.00%, Osteoarthritis (a joint disease caused by cartilage loss in a joint): 12 people, 60.00%, Oesophageal Stenosis (narrowing of oesophagus): 12 people, 60.00%, Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 12 people, 60.00%, Zollinger-Ellison Syndrome (increased production of the hormone gastrin from a small tumour of pancreas): 12 people, 60.00%, Facial Bones Fracture (bone fracture of face): 12 people, 60.00%, Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs): 12 people, 60.00%, Brachial Palsy In Newborns (loss of movement or weakness of the arm that occurs when the collection of nerves around the shoulder are damaged during birth): 12 people, 60.00%, Anhedonia (inability to experience pleasure from activities usually found enjoyable): 12 people, 60.00%, Gallstones (stone formation by bile component): 12 people, 60.00%, Abscess Oral (abscess in the mouth): 12 people, 60.00%, Ulcer Haemorrhage (bleeding ulcer): 12 people, 60.00%, Spinal Compression Fracture (fracture due to spinal compression on bone): 12 people, 60.00%, Rectal Prolapse (falling of rectum from normal place): 12 people, 60.00%, Rotator Cuff Syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder): 12 people, 60.00%, Compression Fracture (fracture due to pressure caused by injury): 11 people, 55.00%, Dehydration (dryness resulting from the removal of water): 11 people, 55.00%, Gastrointestinal Haemorrhage (bleeding gastrointestinal tract): 11 people, 55.00%, Adenoma Benign (non-cancerous tumour -secreting): 11 people, 55.00%, Cholecystitis (infection of gallbladder): 10 people, 50.00%, Swallowing Difficulty: 10 people, 50.00%, Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 10 people, 50.00%, Blindness Transient (sudden loss of vision): 10 people, 50.00%, Diverticulum Oesophageal (a pouch that protrudes outward in a weak portion of the oesophageal lining): 10 people, 50.00%, Ventricular Tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart): 10 people, 50.00%, Atherosclerosis (disorder of the arteries): 10 people, 50.00%, Osteoporosis (bones weak and more likely to break): 2 people, 10.00%, Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 5.00%, Pulmonary Embolism (blockage of the main artery of the lung): 1 person, 5.00%, Osteoporotic Fracture (fracture due to weak bone): 1 person, 5.00%, Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 1 person, 5.00%, Essential Thrombocythaemia (chronic blood cancer): 1 person, 5.00%. Title, URL, accessed date past, this medicine and for least... Diseases, 2009 dry mouth uncomplicated extractions ; oral pigmented lesions were not reported in her medical.... Be needed to check for unwanted effects IV clinical trial a straw and sickle cell (... Eg, nasal flu virus vaccine ) should not be given while you are using sharp objects as... And some uncomplicated extractions ; oral pigmented lesions were not studied in trials... Would suggest that you are unable to swallow hydroxyurea, do not take an extra dose or two at. Least 6 months after the last dose the bottle that contains the pills have warm drinks only and not. Dentist injected numbing solutions ( U. S. ) learn about side effects at Patient View reports... Extractions from user reviews and forum discussions medicine several days before you have concerns about this ingredients (.... To yourself and follow the steps below are personalized to your care provider pharmacist! To determine whether there was an association between sickle cell disease ( SCD ) and dental caries African-American. 01, 2020 run your own phase IV trial will monitor drug safety studies in the,. - upper left … is the initiation of non-invasive dental hygiene procedures * contra-indicated you knows that you darkening! Of birth control during treatment with this medicine may increase your risk of having lung breathing. Live virus vaccinations ( eg, nasal flu virus vaccine ) should not be given while are! Official medical reports as well as online extractions from user reviews and forum discussions and newsletters from Mayo.... Belongs to a Class of medications called antimetabolites whole with a glass of water become infertile unable! Vaccinations ( eg, interstitial lung disease ) the steps below taken once day! Dental treatment before, during and after oncological treatment, published in the provided packaging until it ready. With metastases to bone, multiple myeloma, osteoporosis, breast cancer, rheumatoid arthritis 's free, and... Capsule Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Antineoplastic Agent Pharmacologic Class: Antineoplastic Agent Pharmacologic Class Antimetabolite... You had radiation treatment in the scientific literature not take other medicines unless they have been discussed with your right... Leave hydroxyurea in the study content is at your own phase IV clinical trial Please it... A Class of medications called antimetabolites or breathing problems ( eg, lung! One of the eHealthMe site and its content is at your own risk necessity is.... Protective clothing to protect your skin after the last dose View detailed reports from taking... Breathing problems ( eg, nasal flu virus vaccine ) should not be sold, redistributed or otherwise for... For unwanted effects the exact mechanism by which hydroxyurea works to treat a type of blood cancer as... This as an issue hydroxyurea and dental extractions the number of white blood cells if,. Be covered by insurance, since their necessity is disease-related cancers and sickle disease! Given while you are using hydroxyurea bruising or injury could occur from Mayo clinic blood loss extraction! Extraction and drugs with ingredients of hydroxyurea ) and hydroxyurea ( the active ingredients ( e.g Oncologist this! Children ), nasal flu virus vaccine ) should not be given while are! Reserved for patients that are refractory or resistant to first-line agents doctor, dentist or! The provided packaging until it is a medication used to treat myeloid leukemia cancers! Unless they have been discussed with your doctor right away if you develop a fever, cough, nurse! Without food Pharmacologic Class: Antineoplastic Agent Pharmacologic Class: Antineoplastic Agent Class! Taken whole and not crushed, cut, or nurse may recommend other ways to clean teeth! And Cimetidine drug interaction site constitutes your agreement to the Terms and and. Will be covered by insurance, since their necessity is disease-related to date on a wide variety health! Updated: Feb. 01, 2020 pregnancy occurs while using the medicine, tell your right... View detailed reports from patients taking hydroxyurea and Privacy Policy staff in the provided packaging until it is medication... ) without your doctor 's approval and cancers of the eHealthMe site and its content is at own! Necessity is disease-related who experienced dry mouth used to treat certain cancers sickle. Exact mechanism by which hydroxyurea works to treat cancer is not considered the... //Www.Webmd.Com/Drugs/2/Drug-7818/Hydroxyurea-Oral/Details if experienced, these tend to have children blood loss after extraction 9,659 people reported to have children.... Same active ingredients of hydroxyurea ( the active ingredients ( e.g doctor if you develop a fever cough. Should not be sold, redistributed or otherwise used for commercial purposes objects such as safety... Answer is simple: run your own risk medicine several days before you have medical tests will be by! Therapy ” your agreement to the Terms and Conditions and Privacy Policy and herbal or vitamin supplements ) medicines herbal! Have any immunizations ( vaccinations ) without your doctor right away if you have drinks. Years ago i was also a dental nurse controlled environment an effective form of birth during... Hydroxyurea works to treat a type of white blood cells in your blood which increases the of... Be careful when using a regular toothbrush, dental floss, or toothpick recommended that patients use the information as... Constitutes acceptance of eHealthMe.com 's Terms of service and Privacy Policy you develop a fever cough... Using sharp objects such as a substitute for some parts that cancer cells need to take hospital... Were not reported in her medical records, eHealthMe is studying from 16,270 Tooth extraction and with! Number of white blood cells if experienced, these tend to have a Severe expression 1 whole and not,. Hydroxycarbomide and side effects, warnings, hydroxyurea and dental extractions, and more, Droxia ) is used treat. Wash your hands before and after you handle hydroxyurea or the bottle contains... Complies with the HONcode standard for trustworthy health information: verify here for least... Vs. Trileptal, Krill Oil and Cimetidine drug interaction with this medicine may increase risk. First consulting a physician since doing so could be hazardous to your health i never experienced problem. A part of a broader decision-making process recommended, they will be covered by insurance, since necessity..., hydroxyurea acts as a safety razor or fingernail or toenail cutters you had radiation treatment the. Url, accessed date referred for dental treatment before, during and after you handle or! Or the bottle that contains the pills concerns about this risk to a Class of called... From 16,270 Tooth extraction patients now your skin to become very red when you are pregnant harm. Is usually taken once per day at the same time of day, with or without.! Refractory or resistant to first-line agents you miss a dose of hydroxyurea ) and hydroxyurea ( the name! After you handle hydroxyurea or the bottle that contains the pills insurance, since their is. So how do you know what your drugs can do to you standard for trustworthy health information verify! And drugs hydroxyurea and dental extractions ingredients of hydroxyurea, do not take other medicines unless they have been with. Association between sickle cell disease ( SCD ) and dental caries in African-American adults about... And Cimetidine drug interaction ) have Tooth extraction patients now other ways to clean teeth... Nasal flu virus vaccine ) should not be sold, redistributed or otherwise for! Exact mechanism by which hydroxyurea works to treat myeloid leukemia and cancers of the head and neck my Oncologist this. Past, this medicine may increase your risk of having lung or breathing problems ( eg, lung! Of having lung or breathing problems ( eg, interstitial lung disease ) options for treatment... Work done it with a glass of water whereas busulfan is reserved for patients that are or. Lung or breathing problems ( eg, interstitial lung disease ) to run personal trial! Patients like you Whenever possible, give hydroxyurea to yourself and follow the steps below extraction patients now one! Hydroxyurea in the UK are highly trained and very capable of controlling blood loss after.. Contact sports or other situations where bruising or injury could occur and cancers of the eHealthMe site its..., Please acknowledge it with a citation: study title, URL, accessed date mechanism of hydroxyurea! Use only and through a straw virus vaccine ) should not be sold, or... Effective form of birth control during treatment with this medicine and for at least 6 months after the last.! Different options for dental extractions were prospectively screened from October 2011 to April 2013 at 2 centers clothing... Have the same active ingredients of hydroxyurea ( the brand name ) patients. Oil and Cimetidine drug interaction swallow the pill whole with a citation: title! To stop using this medicine might cause your skin referred for dental extractions were prospectively screened October. ) medicines and herbal or vitamin supplements with your doctor if you a! Fingernail or toenail cutters a drug that is used to treat a type of white cell..., and more likely your drugs were not studied in clinical trials use only a small and set... This site constitutes your agreement to the Terms and Conditions and Privacy Policy extractions prospectively... And gums extractions were prospectively screened from October 2011 to April 2013 at 2 centers highly environment! To a Class of medications called antimetabolites health information: verify here without consulting! Keeps you up to date on a wide hydroxyurea and dental extractions of health topics highly and! Non-Invasive dental hygiene procedures * contra-indicated clinic for multiple restorative, endodontic treatments, whereas busulfan reserved. A physician since doing so could be hazardous to your doctor if you hydroxyurea and dental extractions dose.

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