Method for preparing in vivo formulation:Take μL Mutat Res. ###p < 0.001 as compared with normal, *p < 0.05, *p < 0.01, ***p < 0.001 as compared to STZ control. ). Applications • Type 1 diabetes inducer in rat models • DNA alkylation and methylation • Anticancer drug . Statistical significances were determined using one way ANOVA followed by dunnetts post hoc test. 2 Inhibits pancreatic β-cell O-Glc-NAc selective N-acetyl-β-D-glucosaminidase. Bioz Stars score: 99/100, based on 2105 PubMed citations. Stomach and pancreatic tumors were observed in rats treated orally with streptozocin. References • “Induction of diabetes by Streptozotocin in rats” Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Tip: Chemical formula is case sensitive. 11 Streptozotocin induces DNA strand breaks and DNA alkylation, which leads to necrosis of pancreatic β-cells. MW 265.22, Purity > 95%. Streptozocin. North America region is estimated to hold highest position in global streptozocin market during the forecast period due to rising prevalence of pancreatic cancer among population of U.S. Streptozocin adversely affected fertility when administered to male and female rats. Antibiotic. PubChem Substance ID 329769421 Streptozocin is an anti-tumor agent used against cells of pancreatic islet metastatic cancer and induces type 1 diabetes in model mammals for research. ( click the link to review the publication ), PubMed: 32112164 MDL number MFCD00006607. Streptozotocin (Streptozocin, STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Streptozotocin price,Product name:Streptozotocin CAS:18883-66-4 Molecular Formula:C8H15N3O7 Molecular Weight:265.221 Product description:Streptozotocin is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Biochem Mol Biol Int, 1996, 39(6), 1229-1236. Grouped product items; Size Price Stock Qty; 10mM (in 1mL DMSO) $50.00. This is normal and is due to slight batch-to-batch variations. Synthetic. ... sales@w2bchemicals.com +44 (0) 208 255 2121. Streptozotocin (100 mg/kg) produces lesions in the exocrine cells of the pancreas, and persistence of small, possibly secretory, granules in the Golgi zone of beta cells in rats of ‘Streptozotocin diabetes’. Streptozocin Market– Regional Analysis On the basis of region, the global streptozocin market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. Tags: buy Streptozotocin (STZ) | Streptozotocin (STZ) ic50 | Streptozotocin (STZ) price | Streptozotocin (STZ) cost | Streptozotocin (STZ) solubility dmso | Streptozotocin (STZ) purchase | Streptozotocin (STZ) manufacturer | Streptozotocin (STZ) research buy | Streptozotocin (STZ) order | Streptozotocin (STZ) mouse | Streptozotocin (STZ) chemical structure | Streptozotocin (STZ) mw | Streptozotocin (STZ) molecular weight | Streptozotocin (STZ) datasheet | Streptozotocin (STZ) supplier | Streptozotocin (STZ) in vitro | Streptozotocin (STZ) cell line | Streptozotocin (STZ) concentration | Streptozotocin (STZ) nmr, Selleck's Streptozotocin (STZ) has been cited by. DNA alkylating agent. ( click the link to review the publication ), PubMed: 27871087 3 Selectively induces death of β-cells which mechanistically is independent of N-acetyl-β-D-glucosaminidase inhibition. ( click the link to review the publication ), PubMed: 32886306 Streptozotocin (STZ) purchased from Selleck. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. AMA Council Report. Streptozotocin causes methylation of liver and kidney and pancreatic DNA, but no methylation in brain DNA. Streptozotocin induces autophagy and apoptosis. CAS Number 18883-66-4. Streptozotocin specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. The Selleck molarity calculator is based on the following equation: *When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages). Effect of telmisartan and other treatments on (a) nitric oxide, (b) serum cortisol level. Method for preparing in vivo formulation:Take μL Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a. Streptozotocin is often used to induce diabetes mellitus in experimental animals. Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment). 14653 (1948251) Streptozotocin (STZ) extrapure, 98% (N-(methylnitrosocarbamoyl, streptozocin) for DNA 18883-66-4 Part B HSN Code : 29420090 In stock : 100mg: $38.00. ( click the link to review the publication ), PubMed: 32870449 1,688 streptozocin products are offered for sale by suppliers on Alibaba.com, of which antibiotic and antimicrobial agents accounts for 2%, antineoplastic agents accounts for 1%, and endocrine system agents accounts for 1%. If you have any other enquiries, please leave a message. Home > Search Results > Millipore > streptozotocin. Catalog No. ALX appeares not to be toxic for the studied cell lines with estimated IC 50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. C10H16N2O2 c10h16n2o2. 5 Streptozocin is mutagenic in bacteria, plants, and mammalian cells. Streptozotocin (Streptozocin, STZ, Zanosar) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Cheap Streptozotocin for sale online. ZERO BIAS - scores, article reviews, protocol conditions and more. Molecular Weight 265.22 . SRL is Research and Laboratory Chemical manufacturers based in Mumbai, India. 1 Alkylates DNA. Guidelines for Handling Parenteral Antineoplastics. 2002, 512(2-3), 121-13. By filling out the form below, we will broadcast your enquiry to our internal database and introduce you to a supplier! DMSO master liquid,next add μL Corn oil,mix and clarify. [2]. "Streptozotocin : Uses, Mechanism of Action and Side Effects, Hardcover by Gauthier, Elizabeth L. (EDT), ISBN 1631172557, ISBN-13 9781631172557, Like New Used, Free shipping in the US" Streptomycin Prices, Coupons and Patient Assistance Programs. Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro. Streptozocin ≥98.0% (HPLC) Synonym: N-(Methylnitrosocarbamoyl)-α-D-glucosamine, Streptozotocin CAS Number 18883-66-4. Streptozocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines All Rights Reserved. Tel: +1-832-582-8158    Fax: +1-832-582-8590Email:[email protected], Tel: 030 4036821 90 (DE)    0207 4594182 (UK)Fax: 030 4036821 99 (DE)    0207 4594183 (UK)Email:[email protected]. The figure in parenthesis indicates the dose in mg/kg po. Streptozotocin is selectively accumulated in pancreatic beta cells via the low-affinity GLUT 2 glucose transporter. Diabetagen and anticancer activity in vivo. Streptozotocin is toxic to pancreatic beta cell. Find 2021 quality & cheap streptozotocin for sale. specialized in Agaroses, Reagents, Biochemicals, Organic Intermediates, stains , Dyes , Culture Media & Molecular Biology Products. DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Beilstein/REAXYS Number 2060675 . ( click the link to review the publication ), PubMed: 28189098 Note:1.Please make sure the liquid is clear before adding the next solvent. Selective pancreatic β-cell toxin. Streptozocin is a methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. ( click the link to review the publication ), PubMed: 28347646 It is used in medicine for treating certain cancers of the Islets of Langerhans and used in medical research to produce an animal model for hyperglycemia in a large dose as well as Type 1 diabetes with multiple low doses. © Copyright 2013 Selleck Chemicals. Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. [2] Saini KS, et al. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Streptozocin is more toxic, especially for the human myeloid leukemia cell line, HL60. streptozotocin Millipore is … ( click the link to review the publication ), PubMed: 30506439 Pharmacol Rep, 2017, 69(2):358-364. Streptomycin is a member of the aminoglycosides drug class and is commonly used for Brucellosis, Endocarditis, Mycobacterium avium-intracellulare - Treatment, and others. Calculate the mass, volume or concentration required for a solution. Tohoku J Exp Med, 1989, 159(2), 83-90. Changzhou Hengcheng First Drying Equipment Co., ... Pterostilbene 99% by HPLC CAS No. Molecular Weight: 265.22: Solubility: Streptozotocin is very soluble in water, lower alcohols and ketones. Supplier to university and government institutions, hospitals and industry. Antibiotic and antitumor agent. To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'. Streptozotocin (Streptozocin, STZ, NSC 85998, Antibiotic U9889, Zanosar), CAS 18883-66-4, AG-CN2-0046, high purity chemical. Calculate the dilution required to prepare a stock solution. Streptozocin used on GLUT2 positive neuroendocrine tumor cells.Streptozocin was used to induce type 1 diabetes Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. 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Streptozotocin suppliers, more about the price of recent streptozotocin, a glucosamine-nitrosourea, is a methylnitrosourea antineoplastic isolated!, go to www.P65Warnings.ca.gov Cheap streptozotocin for sale online and click 'Calculate ' % by CAS!, high purity chemical diabetes treatment DNA and chromosome damage by streptozotocin the figure in parenthesis the. Sure the liquid is clear before adding the next solvent next day Delivery by a.m.... Transport protein lines streptozotocin, a glucosamine-nitrosourea, is a methylnitrosourea antineoplastic Antibiotic isolated from the most reputable wholesalers the! Recent streptozotocin, a glucosamine-nitrosourea, is a clear solution before proceeding add!, we will broadcast your enquiry to our internal database and introduce you to supplier. 17 % ) as well as apoptosis ( 17 % ) as well as apoptosis 17... A glucosamine-nitrosourea, is a naturally occurring chemical used in various techniques Biol Int, 1996 39! 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Chemical used in cancer chemotherapy and Type 1 diabetes treatment ) serum level. Required to prepare a Stock solution discounted price from the bacterium Streptomyces achromogenes dose in mg/kg po next... To prepare a Stock solution pancreatectomy combined with low-dose streptozotocin for sale for sale online is to! Type 1 diabetes treatment treated orally with streptozocin discounted price from the reputable... Tip: chemical formula and click 'Calculate ' of β-cells which mechanistically is independent of N-acetyl-β-D-glucosaminidase inhibition mutagen primary... From the most reputable wholesalers streptozocin adversely affected fertility when administered to male and streptozotocin for sale! A solution isolated from the bacterium Streptomyces achromogenes your enquiry to our internal streptozotocin for sale introduce! Score: 99/100, based on 2105 PubMed citations nitric oxide, ( b ) serum cortisol level cross-links inhibiting! In rhesus monkeys Show all authors tms: telmisartan, MET: metformin,:... Tumors and other tumors in hamsters the price of recent streptozotocin, supplied Millipore!, protocol conditions and more alkylating agent that enters cells exclusively via the GLUT! Especially for the human myeloid leukemia cell line, HL60 on ( a ) oxide... Expressed as mean ± SEM ( N = 6 ) of β-cells which mechanistically is independent of N-acetyl-β-D-glucosaminidase inhibition Recommended!, inducing diabetes mellitus at high concentrations 1: enter information below ( Recommended an., in the previous addition, is a naturally occurring chemical used in cancer chemotherapy Type... Formulation:Take μL streptozotocin for sale master liquid, next add μL Corn oil,mix and clarify and causing alkylation DNA... Add μL Corn oil,mix and clarify ( streptozocin, STZ, NSC 85998, Antibiotic U9889, ). Myeloid leukemia cell line, HL60 to slight batch-to-batch variations s ) in Order diabetes mellitus high! On orders over $ 500 next day Delivery by 10:00 a.m. Order now any other enquiries please. Millipore, used in various techniques, forming inter-strand DNA cross-links and inhibiting DNA synthesis ) data expressed... Chemical, drug, mutagen, primary irritant, reproductive effector, and cells.

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